Pentobarbital will decrease the level or effect of prednisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Older adults or those with chronic medical conditions may experience depression, confusion, or excitement after taking the drug. pentobarbital will decrease the level or effect of exemestane by affecting hepatic/intestinal enzyme CYP3A4 metabolism. https://doctorbookmark.com/story20356326/5-fatti-facile-circa-pentobarbital-natrium-descritto